Research progress on genetic factors and ischemic stroke
10.19845/j.cnki.zfysjjbzz.2024.0199
- VernacularTitle:遗传因素与缺血性脑卒中的相关研究进展
- Author:
Fanzhou REN
1
,
2
;
Yuding LUO
;
Jian WANG
Author Information
1. 川北医学院,四川 南充 637000
2. 雅安市人民医院神经内科,四川 雅安 625000
- Keywords:
Ischemic stroke;
Gene variation;
Gene polymorphism;
Genetic susceptibility
- From:
Journal of Apoplexy and Nervous Diseases
2024;41(11):1042-1046
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,as the incidence rate of stroke in China has been increasing,the number of survivors has also been rising,highlighting an urgent need to improve their quality of life and outcome.Recent advances in bioinformat-ics and genomics have unraveled close links between ischemic stroke and genetic factors.This review aims to elucidate the relationship between the risk of ischemic stroke risk and inflammation-related genes,thrombosis-related genes,genetic polymorphisms in vascular diseases,and oxidative stress-related genes,and discuss the pathogenesis and risk prediction of ischemic stroke from the perspectives of genetic variation,genetic susceptibility,epigenetics,and related research methods.These insights may provide a reference for the etiological diagnosis and personalized treatment of ischemic stroke,so as to improve survivor's outcome and quality of life.
