Effects of homocysteine and estimated glomerular filtration rate on neurological function in patients with isch-emic cerebrovascular disease
10.19845/j.cnki.zfysjjbzz.2024.0193
- VernacularTitle:同型半胱氨酸和肾小球滤过率对缺血性脑血管病患者神经功能的影响
- Author:
Yajie GUO
1
;
Meng WANG
;
Yu CHANG
Author Information
1. 天津医科大学,天津 300070
- Keywords:
Ischemic cerebrovascular disease;
Homocysteine;
Glomerular filtration rate;
Modified Rankin Scale;
Interaction
- From:
Journal of Apoplexy and Nervous Diseases
2024;41(11):1012-1017
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the individual and interaction effects of the estimated glomerular filtration rate(eGFR)and homocysteine(Hcy)on the neurological function of patients with ischemic cerebrovascular disease(ICVD)at admission.Methods We included 496 patients with ICVD hospitalized in the Department of Neurology of Tianjin First Central Hospital.Their basic information,disease history,and laboratory test results were recorded.Accord-ing to the modified Rankin Scale(mRS)score,the patients were grouped:good neurological function(0-1 points)and neurological dysfunction(2-5 points).The associations of Hcy and eGFR with the neurological function of patients with ICVD at admission were analyzed by using a multivariable logistic regression model and an additive interaction model.Results Among the 496 patients,236 had neurological dysfunction,while 260 showed good neurological function.After adjusting for confounding factors,eGFR and Hcy were independent influencing factors for the neurological function of the patients at admission(both P＜0.05).The risk of neurological impairment at admission in patients with a high Hcy level and a low eGFR was 4.38 times that of patients who were normal in Hcy and eGFR(OR=4.38,95%CI 2.72-7.14,P＜0.001).Hcy and eGFR had an interactive effect on the risk of neurological dysfunction at admission(RERI=2.01,95%CI 0.02-4.01;AP=0.46,95%CI 0.13-0.79).Conclusion Hcy and eGFR are factors influencing the neurological function of patients with ICVD at admission,and the two indicators have an additive interaction on the risk of neurological dysfunc-tion at admission.
