Research advances in cerebral blood flow regulation in Parkinson disease
10.19845/j.cnki.zfysjjbzz.2024.0185
- VernacularTitle:帕金森病的脑血流调节研究进展
- Author:
Jingrong ZENG
1
;
Baolei XU
;
Erhe XU
Author Information
1. 首都医科大学宣武医院神经内科,北京 100053
- Keywords:
Parkinson disease;
Cerebral blood flow autoregulation;
Cerebral vasomotor reactivity;
Neurovascular coupling
- From:
Journal of Apoplexy and Nervous Diseases
2024;41(11):973-976
- CountryChina
- Language:Chinese
-
Abstract:
Cerebral blood flow directly affects substance metabolism and neural activity in the brain,and it is closely associated with the development and progression of neurodegenerative diseases.The ability for cerebral blood flow regulation directly affects the stability of cerebral blood perfusion,which is an important indicator for evaluating brain function.At present,studies have shown that the reduction in cortical perfusion is closely associated with cognitive decline in patients with Parkinson disease,and orthostatic hypotension often occurs in the late stage of the disease,thereby further increasing the risk of hypoperfusion,which reflects the importance of the ability for cerebral blood flow regulation in Parkinson disease.By reviewing related articles,this article summarizes the mechanism of cerebral blood flow regulation in patients with Parkinson disease,such as cerebral blood flow autoregulation,cerebral vasomotor reactivity,neurovascular coupling,and endothelium-dependent response,so as to provide new ideas and directions for exploring the effect of cerebral blood flow on Parkinson disease.
