Research advances in mitochondrial biogenesis and ischemic stroke
10.19845/j.cnki.zfysjjbzz.2024.0181
- VernacularTitle:线粒体生物发生与缺血性脑卒中研究进展
- Author:
Fenglin CHEN
1
;
Xiaohua SHI
;
Jiaoqi WANG
Author Information
1. 吉林大学中日联谊医院神经内科,吉林 长春 130031
- Keywords:
Ischemic stroke;
Mitochondrial biogenesis;
Neuroprotection
- From:
Journal of Apoplexy and Nervous Diseases
2024;41(10):950-955
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic stroke has become the leading cause of mortality and disability among adults in China.After ce-rebral ischemia,various pathological and physiological pathways,including the increase in oxygen free radicals,inflam-matory response,calcium overload,and energy metabolism disorders,can disrupt cellular homeostasis,cause mitochon-drial dysfunction,and finally lead to cell apoptosis.By generating new functional mitochondria to replace damaged ones and restoring mitochondrial function,mitochondrial biogenesis(MB)is the primary mechanism for maintaining mitochon-drial homeostasis and plays a crucial role in mitochondrial quality control.In recent years,with the in-depth research on the mechanisms of ischemic stroke injury,MB has emerged as a potential therapeutic target.This article reviews the re-search advances in the role and mechanisms of MB in cerebral ischemic injury,in order to provide a theoretical reference for neuroprotective treatment in ischemic stroke.
