Association between inflammatory factor levels and clinical prognosis after mechanical thrombectomy in patients with acute ischemic stroke
10.19845/j.cnki.zfysjjbzz.2024.0177
- VernacularTitle:急性缺血性卒中患者机械取栓术后炎症因子水平与临床预后相关性
- Author:
Rui FENG
1
;
Haojia YU
;
Shimeng XIN
Author Information
1. 大连医科大学附属第二医院神经医学重症科,辽宁 大连 116023
- Keywords:
Acute ischemic stroke;
Mechanical thrombectomy;
Interleukin-2R;
Interleukin-6;
Tumor necro-sis factor-α;
Clinical prognosis
- From:
Journal of Apoplexy and Nervous Diseases
2024;41(10):933-937
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of the levels of interleukin-2R(IL-2R),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α)on the clinical prognosis of patients with acute ischemic stroke(AIS)undergoing me-chanical thrombolysis.Methods A retrospective analysis was performed for 156 AIS patients who underwent mechanical thrombectomy,and related clinical data and laboratory markers of inflammatory factors(IL-2R,IL-6,and TNF-α)were collected.On day 90 after mechanical thrombectomy,the patients were divided into good prognosis group and poor progno-sis group based on modified Rankin Scale(mRS).Univariate and multivariate logistic regression analyses were used to in-vestigate the association between the levels of inflammatory factors and poor prognosis on day 90 after surgery,and the re-ceiver operating characteristic(ROC)curve was plotted to investigate the efficacy of inflammatory factors in predicting poor prognosis.Results The incidence rate of poor prognosis was 67.9%on day 90 after surgery,and after adjustment for confounding factors,the multivariate logistic regression analysis showed that high IL-2R level,high platelet count,bridging therapy,and recanalization with one pull of the bolus were protective factors for the prognosis of AIS patients on day 90 after mechanical thrombolysis[odds ratio(OR)<1,P<0.05],and fasting blood glucose and NIHSS score after thrombectomy were risk factors for poor prognosis on day 90 after mechanical thrombolysis in patients with AIS(OR>1,P<0.05);IL-6 and TNF-α were not independent influencing factors for poor prognosis in patients with AIS on day 90 after mechanical thrombolysis(P>0.05).The ROC curve showed that IL-2R or NIHSS score after thrombectomy used alone or in combination had an area under the ROC curve of 0.801,0.804,and 0.892,respectively,in predicting poor prognosis on day 90 after surgery,and the combination of IL-2R and NIHSS score after thrombectomy had a higher predictive value.Conclusion The high level of IL-2R is independently associated with a good prognosis in AIS patients on day 90 after mechanical thrombolysis,and NIHSS score after thrombectomy combined with IL-2R has better predictive efficacy than NIHSS score after thrombectomy alone.For the time being,no independent effect of IL-6 and TNF-α has been found on the poor prognosis of AIS patients on day 90 after mechanical thrombolysis.
