Research advances in the role of mitochondrial dysfunction in ferroptosis in Alzheimer disease

VernacularTitle:线粒体功能障碍在阿尔茨海默病铁死亡中的作用研究进展
Author: Huimin WU ^{1
,

2} ; Yuanmei WU ; Zhaoming GE
Author Information

1. 兰州大学第二临床医学院,甘肃兰州 730000
2. 兰州大学第二医院神经内科,甘肃兰州 730000
Keywords: Ferroptosis; Mitochondria; Alzheimer disease; Treatment
From: Journal of Apoplexy and Nervous Diseases 2024;41(8):714-717
CountryChina
Language:Chinese
Abstract: Ferroptosis is a novel type of oxidatively regulated cell death driven by iron-dependent lipid peroxidation.As the main site of iron utilization and oxidative metabolism,mitochondria are the main source of intracellular reactive oxy-gen species.Ferroptosis is associated with the severe impairment of mitochondrial structure and function,bioenergetics,and metabolism.Alzheimer disease(AD)is a devastating progressive neurodegenerative disease with the main clinical manifestation of decline in memory and cognitive function.Emerging evidence suggests that mitochondrial dysfunction plays a significant role in the process of ferroptosis in AD.This article elaborates on the mechanism of ferroptosis,mito-chondrial dysfunction and its role in ferroptosis in AD,and the treatment of AD,in order to provide a new perspective for exploring new strategies for the prevention and treatment of AD.