Advances in animal studies on the activation of microglial cells by low-intensity focused ultrasound in treatment of Alzheimer disease
10.19845/j.cnki.zfysjjbzz.2024.0136
- VernacularTitle:低强度聚焦超声活化小胶质细胞治疗阿尔茨海默病的动物研究进展
- Author:
Shuo LI
1
;
Huanliang LIU
;
Huijuan CUI
Author Information
1. 哈尔滨医科大学附属第四医院超声科,黑龙江 哈尔滨 150001
- Keywords:
Alzheimer disease;
Low-intensity focused ultrasound;
Microglial cell;
Blood-brain barrier
- From:
Journal of Apoplexy and Nervous Diseases
2024;41(8):709-713
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer disease is a common neurodegenerative disease among the elderly and has abnormal accumula-tion of amyloid plaques as the typical pathological feature.Because of its strict selective permeability,the blood-brain bar-rier prevents all macromolecular substances from entering the central nervous system and has thus become a"bottleneck"for delivering therapeutic drugs to the brain.Studies have shown that low-intensity focused ultrasound combined with ultra-sound microbubbles can safely and reversibly open the junction between endothelial cells of the blood-brain barrier through cavitation and reduce amyloid deposition by promoting the activation of microglial cells into an anti-inflammatory state.This article reviews the latest research advances in low-intensity focused ultrasound in the treatment of Alzheimer disease,in order to provide a theoretical basis and new strategies for the treatment of Alzheimer disease.
