Research advances in microglial lipid droplet in central nervous system disorders
10.19845/j.cnki.zfysjjbzz.2024.0127
- VernacularTitle:小胶质细胞中的脂滴在中枢神经系统疾病中的研究进展
- Author:
Lilin LI
1
;
Jinglong HU
;
Yun XU
Author Information
1. 南京大学医学院附属鼓楼医院,江苏 南京 210008
- Keywords:
Lipid droplet;
Microglia;
Lipid metabolism;
Central nervous system disorders;
Inflammation
- From:
Journal of Apoplexy and Nervous Diseases
2024;41(7):655-660
- CountryChina
- Language:Chinese
-
Abstract:
Lipid droplet were once simply regarded as depots for neutral lipids,but recent studies have shown that they play an important role in signal transduction,metabolism,and inflammation in glial cells,especially in microglia.Microglia are resident mononuclear phagocytes of the central nervous system and are closely associated with inflammation,phagocytosis,myelin repair,aging,and neurodegenerative diseases.However,further studies are needed to clarify the mechanism of lipid droplet formation in microglia and its influence on histopathology and related diseases.This article summarizes the recent research findings,in order to further clarify these issues.
