Hyperchloraemia with frequent seizures caused by long-term use of topiramate:a case report and literature re-view

VernacularTitle:长期服用托吡酯诱发高氯血症伴频发癫痫1例报告并文献复习
Author: Fei HE ¹ ; Gaozan ZHANG ; Dongliang QI
Author Information

1. 吉林大学中日联谊医院神经内科,吉林长春 130000
Keywords: Topiramate; Hyperchloraemia; Mechanism of action; Epilepsy
From: Journal of Apoplexy and Nervous Diseases 2024;41(7):651-654
CountryChina
Language:Chinese
Abstract: We report a patient who had topiramate use for 4 years to control epilepsy but was repeatedly hospitalized due to frequent seizures since the second year of the treatment,without triggers such as drug withdrawal,drug reduction,irregular treatment,and irregular lifestyles.Intermittent monitoring of ions revealed electrolyte disorders-hyperchlorae-mia,but symptomatic electrolyte correction was always ineffective.After discontinuing topiramate,blood chlorine quickly returned to normal,and epilepsy was successfully controlled.Based on related literature,we further discuss the possible mechanisms of topiramate-induced hyperchloraemia and frequent seizures,aiming to improve the safety of topiramate in clinical application.