Comparison of the application of two chemotherapy-induced oral mucositis assessment tools in children with acute leukemia
10.3760/cma.j.cn115682-20210121-00342
- VernacularTitle:两种化疗相关性口腔炎评估工具在急性白血病患儿中的应用比较
- Author:
Zhengzheng GE
1
;
Xiaoyan ZHANG
;
Nanping SHEN
;
Jiwen SUN
;
Mengxue HE
Author Information
1. 上海交通大学医学院附属上海儿童医学中心血液肿瘤科 200127
- Keywords:
Child;
Hematologic neoplasms;
Chemotherapy-induced oral mucositis;
Children's International Mucositis Evaluation Scale;
Oral Assessment Guide;
Surveying re
- From:
Chinese Journal of Modern Nursing
2021;27(30):4129-4133
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the capabilities of different chemotherapy-induced oral mucositis assessment tools, and seek a credible, reliable, highly sensitive and specific chemotherapy-induced oral mucositis assessment tool suitable for children and adolescents in China.Methods:From July 2019 to June 2020, convenience sampling was used to select 88 children from the Department of Hematology Oncology of Shanghai Children's Medical Center. The Chinese version of Children's International Mucositis Evaluation Scale (ChIMES) , Oral Assessment Guide (OAG) , and World Health Organization (WHO) oral mucositis classification were evaluated for all children in the three time periods, namely, before chemotherapy (T1: before the start of chemotherapy) , early chemotherapy (T2: the first to third days of chemotherapy) , and late chemotherapy (T3: the fourth day of chemotherapy and after) . Taking the result of WHO oral mucositis classification as the gold standard, and indicators such as sensitivity, specificity, relative operating characteristic (ROC) , and area under the curve (AUC) were used to evaluate the capabilities and optimal cut-off values of ChIMES and OAG, and the evaluation time-consuming of the three tools was compared.Results:There were statistically significant differences between ChIMES and OAG in the three scores during chemotherapy ( P<0.05) . Taking the WHO oral mucositis classification as the gold standard, the optimal cut-off value for ChIMES was 0.5, and the optimal cut-off value for OAG was 10.5. Both ChIMES and OAG had excellent assessment capabilities for children with chemotherapy-induced oral mucositis (AUC>0.9) . The time-consuming comparison of WHO oral mucositis classification, ChIMES and OAG was statistically significant ( P<0.05) . Conclusions:Both ChIMES and OAG can be used as credible and reliable tools for the assessment of chemotherapy-induced oral mucositis of children in China. ChIMES is more capable of identifying high-risk groups than OAG, and OAG is more suitable for busy clinical work. The assessment tool for children with chemotherapy-induced oral mucositis can be selected according to the assessment object, purpose, and required resources.
