Pathological changes of cerebellar injury in rats with alcoholism
10.19845/j.cnki.zfysjjbzz.2024.0121
- VernacularTitle:酒精中毒大鼠小脑损伤的病理改变
- Author:
Li ZHAO
1
;
Jikui GUAN
;
Jiafeng CHEN
Author Information
1. 芜湖市第一人民医院,安徽 芜湖 241000
- Keywords:
Alcoholism;
Cerebellar injury;
Pathological change
- From:
Journal of Apoplexy and Nervous Diseases
2024;41(7):626-630
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the pathological changes of cerebellar injury in rats with alcoholism.Methods An animal model of chronic alcoholism was established in Wistar male rats by gavage of 50%edible alcohol at increasing doses for 4 weeks.The pathological changes of cerebellar injury in rats after alcoholism were observed using an optical mi-croscope and a transmission electron microscope.Results Optical microscopy in rats with alcoholism showed signifi-cantly reduced number of granule cells and Purkinje cells in the cerebellum,and significant cell degeneration,especially in Purkinje cells.Electron microscopy showed significantly reduced organelles,irregularly shaped nucleus,and unobvi-ous and irregularly shaped nucleolus in cerebellar capillary endothelial cells.Conclusion Alcoholism induces damages to the cerebellar cells and their ultrastructure,providing a basic theoretical basis for the resulting motor and cognitive dys-function.
