Association of the serum levels of peroxisome proliferator-activated receptor-γ coactivator-1α and fibronectin type Ⅲ domain-containing protein 5 with the severity and prognosis of patients with hypertensive cerebral hemor-rhage
10.19845/j.cnki.zfysjjbzz.2024.0102
- VernacularTitle:血清PGC-1α和FNDC5水平与高血压性脑出血患者病情程度及预后的相关性分析
- Author:
Yifan CAI
1
;
Chenglin LIU
;
Bing LI
Author Information
1. 张家港市第一人民医院神经外科,江苏 张家港 215600
- Keywords:
Hypertensive cerebral hemorrhage;
Peroxisome proliferator-activated receptor-γ coactivator-1α;
Fibronectin type Ⅲ domain-containing protein 5
- From:
Journal of Apoplexy and Nervous Diseases
2024;41(6):533-538
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the serum levels of peroxisome proliferator-activated receptor-γ coactivator-1α(PGC-1α)and fibronectin type Ⅲ domain-containing protein 5(FNDC5)in patients with hypertensive cerebral hemor-rhage and their association with disease severity and prognosis.Methods A total of 80 patients with hypertensive cere-bral hemorrhage who were diagnosed and treated in our hospital from July 2019 to February 2022 were enrolled as case group,and 80 individuals undergoing physical examination were enrolled as control group.ELISA was used to measure the serum levels of PGC-1α and FNDC5,and the receiver operating characteristic(ROC)curve was used to investigate their value in predicting the prognosis of patients with hypertensive cerebral hemorrhage.The logistic regression analysis was used to investigate the influencing factors for poor prognosis in patients with hypertensive cerebral hemorrhage.Results The case group had significantly lower serum levels of PGC-1α and FNDC5 than the control group(P<0.05),and the good prognosis group also had significantly higher serum levels of PGC-1α and FNDC5 than the poor prognosis group.Disease severity,PGC-1α,and FNDC5 were influencing factors for poor prognosis in patients(P<0.05).Serum PGC-1α and FNDC5 alone or in combination had an area under the ROC curve of 0.957,0.937,and 0.985,respec-tively,in predicting poor prognosis in patients with hypertensive cerebral hemorrhage.Conclusion There are low expres-sion levels of PGC-1α and FNDC5 in patients with hypertensive cerebral hemorrhage,which are associated with the sever-ity and prognosis of patients.Both of them are independent protective factors for prognosis and have a certain application value in evaluating prognosis in clinical practice.
