Application of different protection schemes in the configuration of intraperitoneal hyperthermic perfusion chemotherapy drugs in malignant tumor operation
10.3760/cma.j.cn115682-20210131-00497
- VernacularTitle:不同防护方案在恶性肿瘤术中腹腔热灌注化疗药物配置中的应用研究
- Author:
Feng WANG
1
;
Ruixian HE
Author Information
1. 中国医学科学院肿瘤医院手术室，北京 100021
- Keywords:
Hyperthermic intraperitoneal chemotherapy;
Operating Room;
Medical and nursing staff;
Biological safety cabinet;
Occupational exposure
- From:
Chinese Journal of Modern Nursing
2021;27(29):4012-4015
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the dissipation of hyperthermic intraperitoneal chemotherapy (HIPEC) drugs configured in the biological safety cabinet in the Operating Room.Methods:From February 2018 to October 2019, convenience sampling was used to select 60 patients with gastrointestinal malignancies who received HIPEC in the Operating Room of the Cancer Hospital of the Chinese Academy of Medical Sciences as the research object. Patients were divided into four groups according to the order of operation time, with 15 cases in each group. In the control group, there was no protection on the HIPEC configuration table for patients with gastrointestinal malignancies. In the isolation pad group, the HIPEC configuration table for patients with gastrointestinal malignancies was flat with an isolation pad of the same area as the table. In the medical gauze group, the HIPEC configuration table for patients with gastrointestinal malignancies was covered with medical gauze of the same area as the table. In the medical absorbent paper group, the HIPEC configuration table for patients with gastrointestinal malignancies was laid flat with medical absorbent paper of the same area as the table. The four groups all adopted conventional protection methods for the configuration staff, that was, the configuration staff routinely wore special clothing and hats of the Operating Room, wore disposable masks and latex gloves. The positive rate of chemotherapy drugs and the residual cisplatin concentration of each group of countertop samples, glove samples, auricle wipe samples and mask samples were compared.Results:There was a statistically significant difference in the positive rate of drug residues in countertop samples from different groups ( P<0.01) .Among them, the positive rates of countertop samples in the isolation pad group, medical absorbent paper group, and medical gauze group were lower than that of the control group, and the difference was statistically significant ( P<0.01) . There was no statistically significant difference in the positive rate of drug residues in glove samples, auricle wipe samples and mask samples in different groups ( P>0.05) .The difference of drug residue concentration in countertop samples of different groups was statistically significant ( P<0.01) . Among them, the concentration of drug residue in countertop samples of the isolation pad group, medical absorbent paper group, and medical gauze group was lower than that of the control group, and the difference was statistically significant ( P<0.01) .There was no significant difference in drug residue concentration in glove samples, auricle wipe samples and mask samples in different groups ( P>0.05) . Conclusions:Covering the table with isolation pads, medical gauze and medical absorbent paper can effectively reduce the residual concentration of chemotherapy drugs on the biosafety countertop.
