Dynamic changes of signal transducer and activator of transcription 6 and peroxisome proliferator-activated re-ceptor alpha in peripheral blood of patients with acute cerebral infarction and their association with disease sever-ity and prognosis
10.19845/j.cnki.zfysjjbzz.2024.0089
- VernacularTitle:急性脑梗死患者外周血STAT6和PPARα动态变化与病情严重程度及预后的关系分析
- Author:
Na LI
1
;
Feng GUO
;
Wenyun LIU
Author Information
1. 吕梁市人民医院神经内科,山西 吕梁 033000
- Keywords:
Acute cerebral infarction;
Signal transducer and activator of transcription 6;
Peroxisome proliferator-activated receptor alpha;
Dynamic change;
Prognosis
- From:
Journal of Apoplexy and Nervous Diseases
2024;41(5):464-469
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the dynamic changes of signal transducer and activator of transcription 6(STAT6)and peroxisome proliferator-activated receptor alpha(PPARα)in peripheral blood of patients with acute cerebral in-farction(ACI)and their association with disease severity and prognosis.Methods A total of 86 ACI patients who were hospi-talized in our hospital from January 2021 to June 2022 were enrolled as ACI group,and according to the National Institutes of Health Stroke Scale(NIHSS)score,they were divided into mild group with 33 patients,moderate group with 35 patients,and severe group with 18 patients;a total of 85 individuals who underwent physical examination were enrolled as control group.ELISA was used to measure the level of STAT6 in peripheral blood;quantitative real-time PCR was used to measure the mRNA level of PPARα in peripheral blood;an automatic biochemical analyzer was used to measure blood-related biochemical param-eters,and an automatic blood pressure instrument was used to measure blood pressure parameters;a Pearson correlation analy-sis was used to investigate the correlation of STAT6 and PPARα levels with NIHSS score on admission.Results There were significant differences between the control group and the ACI group in triglycerides,low-density lipoprotein cholesterol,lipo-protein,diastolic pressure,and systolic pressure(P<0.05).The ACI group showed gradual reductions in the levels of STAT6 and PPARα in peripheral blood on days 1,3,and 7 of stroke,with the lowest levels observed on day 7 of stroke,and there were increases in the levels of STAT6 and PPARα on day 14 of stroke,which was still lower than the levels in the control group(P<0.05).For the ACI patients,the expression levels of STAT6 and PPARα in peripheral blood tended to decrease gradually with the aggravation of disease conditions at different time points of stroke.The Pearson correlation analysis showed that the levels of STAT6 and PPARα in peripheral blood of ACI patients on day 1 of stroke were negatively correlated with NIHSS scores(P<0.05).The good prognosis group had significantly higher levels of STAT6 and PPARα than the poor progno-sis group at different time points of stroke(P<0.05).Conclusion There are reductions in the levels of STAT6 and PPARα in peripheral blood of ACI patients after the onset of ACI,which tend to first decrease and then increase over the time of stroke,and the changes in the levels of STAT6 and PPARα are associated with the severity and prognosis of ACI patients.
