Human papillomavirus and p53 protein immunoreactivity in condylomata acuminatum and squamous cell carcinoma of penis
- Author:
ZHANG XIN-HUA
1
;
SUN GUI-QIN
;
YANG YU
;
ZHANG TAI-HE
Author Information
1. General Hospital of Nanjing Command PLA
- Keywords:
condylomata acuminata;
penile diseases;
carcinoma;
HPV;
protein p53
- From:
Asian Journal of Andrology
2001;3(1):75-77
- CountryChina
- Language:Chinese
-
Abstract:
To determine the immunoreactive pattem of human papillomavirus (HPV) antigen and p53 protein in condylomata acuminatum (CA) and squamous cell carcinoma (SCC) of penis. Methods: Immunohistochemistry for HPV and p53 were performed in 40 specimens of formalin fixed, paraffin embedded tissues using a polyclonal (rabbit) antibody against HPV and a monoclonal (mouse) antibody against human p53 protein. Twenty one cases of CA and nineteen cases of SCC were examined. Results: HPV antigen was detected in all 21 CA and 2 penile SCC. p53 protein overexpression was observed in 12 of 19 (63%) SCC in which 6 cases were strong positive. Five of 21 CA (24%)showed low-grade p53 protein overexpression. Conclusion: CA is related to HPV infection and some cases show p53 protein low-grade overexpression. In contrast, p53 protein overexpression is common in penile SCC, which is seldom related to HPV infection.
