HIC Value of Mild Traumatic Rats under Anterior-Posterior and Lateral-Medial Craniocerebral Impact:An Equivalent Study
10.16156/j.1004-7220.2024.04.024
- VernacularTitle:轻度创伤型大鼠颅脑前后向-侧向碰撞HIC值等效研究
- Author:
Guoxiang WANG
1
;
Linna ZHU
;
Xun WANG
;
Qiuju CHEN
;
Tao XIONG
;
Qinghang LUO
;
Jia YU
;
Jingyu XU
;
Zhiyong YIN
;
Shengxiong LIU
Author Information
1. 重庆理工大学 药学与生物工程学院,重庆 400054
- Keywords:
histopathology;
motor evoked potential;
brainstem pyramidal tract;
head injury criterion;
craniocerebral impact
- From:
Journal of Medical Biomechanics
2024;39(4):730-735
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the equivalent conversion of head injury criterion(HIC)under anterior-posterior(AP)and lateral-medial(LM)craniocerebral impact for mild craniocerebral injury in rats using motor evoked potential(MEP)and β-amyloid precursor protein(β-APP)immunohistochemistry(IHC).Methods Sixty healthy adult male SD rats were randomly divided into 0 m control group,0.5 m-AP and 0.5 m-LM injury groups,and 1 m-AP and 1 m-LM injury groups(12 rats in each group).The control group did not undergo any impact injury experiment.After the impact injury experiment,the injury and control groups were subjected to excessive anesthesia to produce β-APP immunohistochemical stained slices,and the percentage of positive area and integral optical density(IOD)in the brainstem pyramidal tract area of the slices were determined.The MEP groups were divided in the same manner as the IHC groups and the MEP amplitudes of the MEP and control groups were measured after the impact injury experiment.Results With an increase in the degree of injury,the decrease in MEP amplitude,percentage of positive areas,and IOD in the injury groups significantly increased.When the degree of injury was low,the sensitivity of IHC was higher than that of MEP.When the degree of injury was the same,the HIC in the LM direction was lower than that in the AP direction.When the HIC was the same,the degree of injury in the LM direction was greater than that in the AP direction.Conclusions The joint evaluation of MEP and β-APP can provide experimental references for the study of HIC equivalent conversion in AP-LM craniocerebral impact injury.
