Research Progress on Mechanobiology of Mitochondria
10.16156/j.1004-7220.2024.03.025
- VernacularTitle:线粒体的力学生物学研究进展
- Author:
Jing NA
1
,
2
,
3
;
Lisha ZHENG
;
Yubo FAN
Author Information
1. 北京航空航天大学生物与医学工程学院
2. 生物力学与力生物学教育部重点实验室
3. 北京市生物医学工程高精尖创新中心,北京 100083
- Keywords:
mitochondria;
biomechanical microenvironment;
mechanotransduction;
tissue regeneration;
cancer
- From:
Journal of Medical Biomechanics
2024;39(3):545-551
- CountryChina
- Language:Chinese
-
Abstract:
Mitochondria are highly dynamic organelles,which not only provide energy and material basis for cells,but also regulate cell proliferation,migration,differentiation,and apoptosis.Cell fate is regulated by mechanical cues from the microenvironment.Recent studies have shown that energy metabolism is regulated by mechanical cues.Mitochondria can act as mechanical sensors and hubs that connect the mechanics and metabolism to regulate cell fate.A deep understanding of the relationship between the mechanical microenvironment and mitochondrial metabolism provides sufficient guidance for promoting tissue regeneration and treating diseases.In this review,the progression in mitochondrial mechanobiology is mainly introduced and its potential applications in tissue regeneration and disease treatment are explored.
