Research Progress of Cellular Mechanoperception &Mechanotransmission under Space Microgravity

VernacularTitle:空间微重力下细胞力学感知-传导的研究进展
Author: Ran TIAN ^{1
,

2
,

3} ; Xintong WU ; Lianwen SUN
Author Information

1. 北京航空航天大学生物与医学工程学院
2. 生物力学与力生物学教育部重点实验室
3. 北京市生物医学工程高精尖创新中心,北京 100191
Keywords: space microgravity; cytoskeleton; mechanoperception; mechanotransmission
From: Journal of Medical Biomechanics 2024;39(3):387-392
CountryChina
Language:Chinese
Abstract: On the earth,the majority of cellular functions are regulated by mechanical loads.The effects of cell response to mechanical loads under microgravity on the adaptive changes of physiological functions in space cannot be ignored.The cytoskeleton is widely considered as one of the key structures through which cells sense gravity variation and respond to mechanical loads.In this review,the research progress on the changes and mechanisms of the'cytoskeleton-LINC complex-nuclear lamina'pathway in cellular mechanoperception and mechanotransmission under microgravity is summarized,and the future research is prospected.