Compatible Stability of Esketamine,Sufentanil,Butorphanol and Metoclopramide in 0.9%Sodium Chloride Injection
10.3870/j.issn.1004-0781.2024.12.026
- VernacularTitle:艾司氯胺酮舒芬太尼布托啡诺甲氧氯普胺在0.9%氯化钠注射液中配伍稳定性考察
- Author:
Manman YAO
1
,
2
;
Dan JIANG
;
Jinguo YANG
;
Huanqi CUN
;
Baoxia FANG
;
Fuchao CHEN
Author Information
1. 湖北医药学院药学院,十堰 442000
2. 湖北医药学院附属国药东风总医院药学部,十堰 442008
- Keywords:
Esketamine hydrochloride;
Sufentanil citrate;
Compatible stability;
High performance liquid chromatography;
Content determination;
Insoluble particles
- From:
Herald of Medicine
2024;43(12):2033-2038
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the compatible stability of esketamine hydrochloride,sufentanil citrate,butorphanol tartrate,and metoclopramide in 0.9%sodium chloride injection,and to provide a reference for the rational use of medication for postoperative analgesia.Methods The four drugs were compounded by simulating the clinical concentrations of the drugs,and the samples were taken at 0,4,8,12,24 and 48 h under light-shielded and light-exposed conditions at room temperature.The appearance,pH value,relative drug content,and insoluble particles were determined.Results The appearance of esketamine hydrochloride,sufentanil citrate,butorphanol tartrate,and metoclopramide concoction was clear at 48 h.The pH values were in the range of 4.69 to 4.79,and the relative drug content of the four drugs were in the range of 95%to 105%.The number of insoluble particles exceeded the specified range in the Chinese Pharmacopoeia(2020 edition)at 4 h and 8 h.Conclusions Under light-shielded and light-exposed conditions at room temperature,the appearance,pH value and relative drug content of the compounded solution remained stable for 48 h.However,the number of insoluble particles exceeded the specified standard.Therefore,it is not recommended to mix the above 4 drugs with 0.9%sodium chloride injection for use in analgesic pumps.
