Monitoring and Analysis of Blood Concentrations of Seven New Antiepileptic Drugs on 6 537 Cases in A Grade-A Tertiary Hospital in Beijing
10.3870/j.issn.1004-0781.2024.12.025
- VernacularTitle:北京某三甲医院6537例7种新型抗癫痫药物血药浓度监测与分析
- Author:
Xintian LI
1
;
Dongjie ZHANG
;
Li YANG
;
Zhigang ZHAO
;
Shenghui MEI
;
Jiping HUO
Author Information
1. 首都医科大学药学院,首都医科大学第五临床医学院,北京 100070
- Keywords:
New antiepileptic drugs;
Therapeutic drug monitoring;
Blood concentration;
Concomitant medication;
Epilepsy
- From:
Herald of Medicine
2024;43(12):2026-2032
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the blood concentration monitoring results of 7 new antiepileptic drugs levetiracetam(LEV),oxcarbazepine(OXC),lamotrigine(LTG),topiramate(TPM),lacosamide(LCM),zonisamide(ZNS)and perampanel(PER)and provide a basis for clinical rational drug use.Methods Aretrospective analysis was conducted on the blood concentration monitoring results of 7 new antiepileptic drugs in a grade-A tertiary hospital in Beijing from November 2021 to March 2023,with a total of 6 537 valid concentration data collected.The patients were grouped according to age,gender and concomitant medication,and the blood drug concentration levels and compliance rates among the groups were analyzed and compared.Results The male to female patient ratio was 1.35∶1.There were statistically significant differences in the blood concentration distribution of OXC,LEV,LCM and TPM between genders(P<0.05).The blood concentration of LEV showed statistically significant differences between the pediatric group and the elderly group,as well as between the young adult group and the elderly group(P<0.05).The blood concentrations of OXC,ZNS and TPM showed statistically significant differences between the pediatric group and the young and middle-aged group,between the young and middle-aged group and the elderly group,and between the pediatric group and the young and middle-aged group,respectively(P<0.05).The highest and lowest overall compliance rates of blood concentration were observed for OXC and LCM,respectively.The compliance rates of OXC and TPM in the pediatric group were significantly higher than those in the young-middle-aged group,with statistically significant differences(P<0.05),while the compliance rate of LEV in the elderly group was significantly higher than that in the pediatric group and the young-middle-aged group,with a statistically significant difference(P<0.05).There were a total of 2 133 cases with combined drug use.LEV,OXC and LTG are frequently used and have good efficacy and weak interactions when added to treatment.Conclusion New antiepileptic drugs show a promising prospect in treatment,and therapeutic drug monitoring can further improve the effectiveness of individualized clinical treatment.
