Preparation and Transdermal Absorption Study In Vitro of Zishen Gel Plaster
10.3870/j.issn.1004-0781.2024.12.023
- VernacularTitle:滋肾凝胶贴膏剂的制备及其体外透皮吸收研究
- Author:
Cheng ZHANG
1
;
Jie WANG
;
Yuchen WEI
;
Xiaoxi SUN
;
Hao LU
;
Hanlin XU
Author Information
1. 湖北中医药大学药学院,武汉 430065
- Keywords:
Zishen gel plaster;
Prescription optimization;
Response surface;
Content determination;
Transdermal absorption
- From:
Herald of Medicine
2024;43(12):2013-2020
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare Zishen pills as gel plaster according to the prescription,and investigate its transdermal absorption characteristics in vitro.Methods Based on preliminary experiments,the matrix prescription of the gel plaster was optimized by single-factor tests and the Box-Behnken design.Evaluation indicators included initial viscosity,viscosity retention and sensory scores.The modified Franz diffusion cell was used to investigate the effect of penetration enhancers on the transdermal characteristics of gel plaster in vitro,with the permeability of neomangiferin,phellodendrine hydrochloride,mangiferin and berberine hydrochloride as evaluation indicators.Results The prescription dosage of the preferred matrix for the Zishen gel plaster was sodium polyacrylate NP700 2.55 g,glycerin 11.04 g,polyvinylpyrrolidone K90 1.13 g,tartaric acid 0.1 g,glycyrrhizin 0.1 g,kaolin 0.3 g,and distilled water 15 g.Among different types and concentrations of permeation enhancers,5%aminoketone showed the best permeation performance.The permeation rates for neomangiferin,phellodendrine hydrochloride,mangiferin,and berberine hydrochloride were 1.5338,1.7809,2.3247 and 20.0899 μg·(cm2)-1·h-1,and the penetration rates were 2.4319,1.9408,1.9604 and 1.4701,respectively.The percutaneous absorption curve of the drug conformed to the zero-order kinetic equation.Conclusion The preparation process of the obtained gel plaste is stable and feasible,with good adhesive properties,sustained drug release,and favorable in vitro percutaneous permeability,indicating potential clinical application value.
