Meta-analysis of Clinical Efficacy and"Disease-Symptom-Formula"Associated Mechanism Investigation of Shangke Jiegu Tablet Against Fractures
10.3870/j.issn.1004-0781.2024.12.008
- VernacularTitle:伤科接骨片治疗骨折临床效果的Meta分析及其"病-症-方"关联功效机制
- Author:
Xueting LIU
1
;
Lin CHEN
;
Suya ZHANG
;
Haoying XI
;
Ning ZHANG
;
Na LIN
;
Yanqiong ZHANG
Author Information
1. 中国中医科学院中药研究所,北京 100070
- Keywords:
Shangke Jiegu tablet;
Fracture;
Meta-analysis;
Network pharmacology;
Clinical efficacy;
"Disease-Symptom-Formula"association
- From:
Herald of Medicine
2024;43(12):1919-1929
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study systematically evaluated the clinical efficacy of Shangke Jiegu tablet in the treatment of fracture,and explored the mechanism of action of Shangke Jiegu tablet and the compatibility of each efficacy group from the"Disease-Symptom-Formula"perspective.Methods Clinical research literatures on the use of Shangke Jiegu tablet for fracture intervention were retrieved from Chinese databases(CNKI,Wanfang Database,VIP database)and English databases(PubMed,Cochrane Library,EMbase),covering the period from the inception of the databases to January 2024.Risk assessment tools were used to evaluate the literature's quality,and the data were extracted and analyzed using Stata 16.0 software.Gene sets associated with fracture symptoms were identified through the TCMIP platform(version 2.0).Differential gene expression related to fractures was obtained from the GEO database.Chemical composition and candidate target profiles of the 12 herbs in Shangke Jiegu tablets were collected from TCMIP v 2.0.An interaction network between fracture-related genes and drug candidate targets was established,and core network targets were screened based on topological features,with functional enrichment analysis performed.Results A total of 14 articles were incorporated into the Meta-analysis,encompassing a total sample size of 1 293 cases,indicating an overall response rate of Shangke Jiegu tablets in fracture therapy(RR=1.24,95%CI:1.18-1.31,P<0.001).The"Disease-Symptom-Formula"association network analysis indicated that the pathways related to the putative targets of Shangke Jiegu tablet were primarily involved in bone healing,nerve and blood system regulation,and immune-inflammation regulation.Different efficacy groups within the prescriptions showed varying emphases on these roles.Conclusions Shangke Jiegu tablet may facilitate fracture healing by regulating blood and nervous systems,correcting immune-inflammatory imbalances,and maintaining bone and energy metabolism.The comprehensive effects include the dissipation of blood stasis,the promotion of blood circulation,the alleviation of swelling and pain,the regeneration of muscles and bones,and the clearance of heat and detoxification.These findings support the clinical advantages and positioning of Shangke Jiegu tablet.
