Interpretation of the European Respiratory Society Guidelines for the Diagnosis and Management of Pulmonary Alveolar Proteinosis
10.3870/j.issn.1004-0781.2024.12.001
- VernacularTitle:《欧洲呼吸学会肺泡蛋白沉积症诊断和管理指南》解读
- Author:
Dong XU
1
;
Liru QIU
;
Xiaoping LUO
;
Xiuyun ZHOU
;
Yongjian HUANG
Author Information
1. 华中科技大学同济医学院附属同济医院儿科,武汉 430073
- Keywords:
Pulmonary alveolar proteinosis;
Clinical diagnosis;
Clinical treantment;
Management guidelines;
Interpretation of guidelines
- From:
Herald of Medicine
2024;43(12):1869-1873
- CountryChina
- Language:Chinese
-
Abstract:
To improve the understanding of clinicians on the diagnostic criteria and treatment principlis of pulmonary alveolar proteinosis(PAP),which is a rare respiratory disease.European Respiratory Society published the first edition guidelines for PAP,including a systematic review of the literature and the application of the grading of recommendations,assessment,development and evaluation(GRADE)approach to assess the certainty of evidence and the strength of recommendations.Five questions of patient,intervention,comparison,outcome(PICO)and two narrative questions were developed.Recommendations and evidence-based evidence were given,including management of PAP,whole lung lavage,granulocyte-macrophage colony-stimulating factor(GM-CSF)therapy,rituximab,plasma exchange,and lung transplantation.In addition,recommendations were given for the use of GM-CSF antibody testing,bronchoalveolar lavage,and lung biopsy.This study is to interpret the main content of the guideline.
