Research Progress of Regulating Mechanism and Traditional Chinese Medicine Intervention of Iron Lipid Metabolic Disorder Based on Ferroptosis
10.3870/j.issn.1004-0781.2024.11.019
- VernacularTitle:基于铁死亡探讨铁脂代谢紊乱的调节机制及中药干预的研究进展
- Author:
Shuwen WANG
1
;
Xufeng BAI
;
Qingyu CAO
;
Yali LIU
;
Huiming HU
;
Yanchen ZHU
Author Information
1. 江西中医药大学药学院,南昌 330004
- Keywords:
Traditional Chinese medicine;
Ferroptosis;
Lipid metabolism;
Lipid peroxidation;
Iron metabolism
- From:
Herald of Medicine
2024;43(11):1816-1821
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a form of iron-dependent cell death caused by a disorder of iron lipid metabolism.Its mechanism mainly includes lipid metabolism and iron metabolism,which are complicated and strictly regulated by various metabolic and signaling pathways.Current studies have shown that ferroptosis is associated with cancer,atherosclerosis,and neurological diseases.Traditional Chinese medicine(TCM)is characterized by various active ingredients,relatively high safety,and lower treatment costs,which possess unique advantages in clinical applications.It has been widely used in the treatment of various diseases.Taking the regulation of ferroptosis by traditional Chinese medicine as the entry point may be a new direction for the future prevention and treatment of various diseases.In this review,we discussed the mechanism of iron lipid metabolic disorders based on ferroptosis and the research progress of traditional Chinese medicine intervention to provide reference and treatment strategies for the prevention and treatment of related diseases.
