The Adjuvant Analgesic Effect of Magnesium Sulfate and Its Application Prospect in Non-Opioid Anesthesia Regimen
10.3870/j.issn.1004-0781.2024.10.020
- VernacularTitle:硫酸镁辅助镇痛效果及在无阿片类药物麻醉方案中的应用前景
- Author:
Jie CHEN
1
;
Xiaohai WANG
;
Chunyan TANG
;
Weihong GE
Author Information
1. 南京大学医学院附属鼓楼医院麻醉科,南京 210008
- Keywords:
Magnesium sulfate;
Opioid-free anesthesia;
Pain treatment;
Adjuvant analgesia;
Multimodal analgesia
- From:
Herald of Medicine
2024;43(10):1651-1655
- CountryChina
- Language:Chinese
-
Abstract:
During the pain treatment process,to reduce the use of opioids,alternative pain relievers have been used.Increasing data indicated that N-methyl-D-aspartic acid(NMDA)receptor antagonists may enhance the analgesic effect of opioids.Furthermore,numerous studies have shown that the auxiliary analgesic effect of magnesium sulfate has a good application prospect in pain treatment and perioperative anesthesia.The primary pharmacological mechanism of magnesium sulfate in pain treatment is that it acts as a physiological voltage-dependent blocker of NMDA coupling channels,and its anti-nociceptive effect is related to magnesium blocking calcium inflow,thereby inhibiting central sensitization and reducing preexisting hyperalgesia.This paper reviewed the current application of magnesium sulfate in perioperative period,focusing on its auxiliary analgesic effect through intravenous,intrathecal,and local administration,and the reduction of opioid consumption.As well as its potential role and application prospects in opioid-free anesthesia program.
