Effects of oral immunotherapy for the prevention of ventilator-associated pneumonia in premature infants: a Meta-analysis
10.3760/cma.j.cn115682-20201125-06389
- VernacularTitle:口腔免疫疗法对预防早产儿呼吸机相关性肺炎的Meta分析
- Author:
Huiwen CAI
1
;
Yuelan MA
;
Yongshu LIU
;
Ting SHEN
;
Shiping FENG
;
Xiaojing HU
Author Information
1. 南京医科大学附属苏州医院护理部 215000
- Keywords:
Infant, premature;
Colostrum;
Pneumonia, ventilator-associated;
Oral immunotherapy;
Meta-analysis
- From:
Chinese Journal of Modern Nursing
2021;27(19):2563-2569
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To systematically evaluate the intervention effect of oral immunotherapy (OIT) on ventilator-associated pneumonia (VAP) of premature infants.Methods:This study searched the Cochrane Library, PubMed, Embase, Web of Science, CINAHL, Chinese Biomedical Literature Service System, China National Knowledge Infrastructure (CNKI) , WanFang Database and VIP Database, and conducted a comprehensive search for randomized controlled trials of OIT applied to premature infants published from database establishment to October 2020. Two researchers independently screened literature, extracted data, and evaluated methodological quality. RevMan 5.3 software was used for Meta-analysis.Results:A total of 8 studies were included, with a total of 351 premature infants in the intervention group and 352 premature infants in the control group. Meta-analysis results showed that OIT could reduce the incidence of VAP in premature infants [ RR=0.36, 95% CI (0.23-0.56) , P<0.05] and the detection rate of pathogenic microorganisms in the tracheal tube [ RR=0.33, 95% CI (0.18-0.59) , P=0.000 2], and could shorten the length of hospital stay [ MD=-6.70, 95% CI (-13.34--0.06) , P=0.05]. However, there was no statistically significant difference in the mechanical ventilation time, detection rate of oropharyngeal pathogenic microorganisms and mortality rate between the two groups after the intervention (all P>0.05) . Conclusions:OIT can reduce the incidence of VAP in premature infants and the detection rate of pathogenic microorganisms in the tracheal tube, and shorten the length of hospital stay to a certain extent. However, high-quality, large-sample, multi-center randomized controlled studies are still needed for further verification in the future.
