Advances in Immunological Studies of Targeted Radionuclide Therapy
10.3870/j.issn.1004-0781.2024.10.010
- VernacularTitle:放射性核素靶向治疗的免疫学研究进展
- Author:
Liping YANG
1
;
Yuxuan ZHENG
;
Zhuoling RAN
;
Rui HU
;
Yuwei LIANG
;
Yue SUN
;
Chang LU
;
Huijie LI
;
Xuhan LI
;
Jian GONG
Author Information
1. 沈阳药科大学药物流行病与临床药物评价课题组,沈阳 110016
- Keywords:
Targeted radionuclide therapy;
Immune response;
Alpha nuclide;
Beta nuclide
- From:
Herald of Medicine
2024;43(10):1598-1602
- CountryChina
- Language:Chinese
-
Abstract:
The killing effect of radiation therapy on healthy cells has led to the creation of targeted radionuclide therapy,which effectively reduces the damage to surrounding normal cells.At present,alpha(α)and beta(β)radionuclides are the research hotspots of targeted therapy.Numerous preclinical and clinical studies have shown that radiation therapy not only has local anti-tumor effects,but also exerts systemic anti-tumor effects by triggering the body's immune response.This paper describes in detail the characteristics and clinical applications of commonly used radionuclides,and discusses the mechanism of radiation-triggered body immune response as well as the related research on the combined use of radiation therapy,targeted radionuclide therapy and immunotherapy.
