Correlation Between Ceftazidime-avibactam Blood Concentration and Efficacy in Critically Ill Patients and Influential Factors
10.3870/j.issn.1004-0781.2024.08.018
- VernacularTitle:重症患者头孢他啶阿维巴坦血药浓度与疗效的相关性及影响因素研究
- Author:
Shurun AN
1
;
Li LIAO
;
Huanyan PAN
;
Xiaoxuan YANG
;
Wei ZHANG
;
Xiaoliang CHENG
;
Weihong GE
;
Xuemei LUO
;
Yujie ZHOU
Author Information
1. 中国药科大学南京鼓楼医院药学部,南京 210008
- Keywords:
Ceftazidime-avibactam(CAZ-AVI);
Critically ill patients;
Blood concentration;
Efficacy;
Influencing factors
- From:
Herald of Medicine
2024;43(8):1291-1295
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relationship between ceftazidime-avibactam(CAZ-AVI)blood concentrations and efficacy in critically ill patients and to investigate the factors influencing blood levels.Methods The CAZ-AVI trough concentrations(Cmin)were detected in 29 patients who received CAZ-AVI treatment for at least 48 hours.The clinical materials of the patients were collected together for retrospective analysis.Results The Cmin of ceftazidime(CAZ)and avibactam(AVI)were(50.95±5.17)and(7.52±0.96)mg·L-1 in the effective group and(31.16±7.03)and(5.37±1.32)mg·L-1 in the ineffective group,respectively.The Cmin of CAZ in the effective group was significantly higher than in the ineffective group(P<0.05),and there was no significant difference in AVI Cmin between the two groups(P>0.05).Spearman's correlation analysis showed that CAZ Cmin was positively correlated with clinical efficacy(P<0.05),and no correlation between AVI Cmin and clinical efficacy(P>0.05).The optimal CAZ Cmin threshold was 24.59 mg·L-1.Multiple linear regression analysis showed that age and creatinine clearance was significantly correlated with the Cmin of CAZ,and creatinine clearance was significantly correlated with AVI Cmin(P<0.05).Conclusions The Cmin of CAZ correlates with efficacy,and it may be more beneficial for clinical treatment to keep the concentration of CAZ-AVI always greater than the minimum inhibitory concentration during the dosing interval.The creatinine clearance should be fully considered when optimizing CAZ-AVI dosage in critically ill patients.
