Feasibility and Effectiveness of Midazolam Oral Solution in Sedation for Infants During Echocardiographic Examination
10.3870/j.issn.1004-0781.2024.08.017
- VernacularTitle:咪达唑仑口服溶液用于幼儿超声心动图检查镇静的可行性和效果
- Author:
Xiaoxuan LI
1
;
Jianwen SHI
;
Xiaoxu WANG
;
Rong WANG
;
Weiwei ZHOU
;
Fei LIU
;
Yongxin LIANG
;
Wenjie FAN
Author Information
1. 青岛大学附属妇女儿童医院麻醉中心,青岛 266034
- Keywords:
Midazolam oral solution;
Chloral hydrate;
Infants;
Sedation;
Echocardiography
- From:
Herald of Medicine
2024;43(8):1286-1290
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the acceptability and effectiveness of different doses of midazolam oral solution in sedating infants during echocardiographic studies.Methods Two hundred and fourty patients aged 1 to 3 years who underwent echocardiographic study in sedation in our hospital were enrolled in this study.After recording the baseline data of all infants,they were randomly divided into four groups:0.3 mg·kg-1 midazolam oral solution group(M1 group),0.5 mg·kg-1 midazolam oral solution group(M2 group),0.7 mg·kg-1 midazolam oral solution group(M3 group)and 0.5 mL·kg-1 10%chloral hydrate administrated rectally group(C group),60 case per group,and the sedation was performed in the corresponding method of each group.The 5-point facial hedonic and Ramsay scales were used to evaluate acceptability and effectiveness in sedation.The onset time and duration time of sedation were recorded.Results Compared with the C group,the 5-point facial hedonic scale scores in M1,M2,and M3 groups increased during sedation(F=17.50,P<0.017).The onset time of sedation in the M1 and M2 groups was longer than that in the C group(P<0.017),and the duration time of sedation in the M1 and M2 groups was shorter than that in the C group(P<0.017).There was no significant difference in the onset time(P=0.85)and duration time(P=0.50)of sedation between the M3 and C groups.The onset time of sedation in the M1and M2groups was longer than that in the M3 group(P<0.017),and the duration time of sedation in the M1 and M2 groups were shorter than that in the M3 group(P<0.017).Conclusions The acceptability of infants with midazolam oral solution sedation under echocardiographic study was better than that of 10%chloral hydrate administrated rectally.There were fewer adverse reactions with the midazolam oral solution.The 0.7 mg·kg-1 midazolam oral solution had a rapid onset of sedation and definite effect.
