Alternative Drug Delivery Methods for Novel Oral Anticancer Drugs in Patients with Dysphagia

VernacularTitle:吞咽困难患者新型口服抗肿瘤药物的替代给药方法
Author: Zihan GUO ^{1
,

2} ; Honglu ZHANG ; Xianchun DAI ; Zhisheng ZHANG ; Jiyong LIU ; Mengmeng WANG ; Qiong DU
Author Information

1. 复旦大学附属肿瘤医院药剂科,上海 200032
2. 复旦大学上海医学院肿瘤学系,上海 200032
Keywords: Novel oral anticancer drugs; Dysphagia; Alternative drug delivery method
From: Herald of Medicine 2024;43(8):1278-1285
CountryChina
Language:Chinese
Abstract: Objective To provide alternative delivery methods of novel oral antitumor drugs for patients with dysphagia.Methods The retrieval range was determined according to the"Guidelines for Clinical Application of Novel Antitumor Drugs(2022 edition)".By consulting the instructions and searching databases such as PubMed,Micromedex,UpToDate,etc.,the preparation,stability,storage,and related clinical information of temporary liquid drug formulations were obtained.Results Seventy novel oral anticancer drugs were included in the literature search.Thirty-three drugs had relevant literature or data supporting alternative administration methods,only eight had information on alternative administration in the instructions,and the level of evidence for other drugs varied.Conclusion The evidence levels were low for most temporary liquid formulations,and medical teams should fully consider the advantages and disadvantages of using these products outside the instructions and use them with caution.