Research Progress of Pyroptosis in Anti-tumor Nanodelivery System

VernacularTitle:细胞焦亡在抗肿瘤纳米递送系统中的研究进展
Author: Yan CHEN ^{1
,

2} ; Sanjun SHI ; Dandan MI ; Rujing WANG ; Hongtao XIAO
Author Information

1. 四川省肿瘤临床医学研究中心、四川省肿瘤医院研究所、四川省肿瘤防治中心、电子科技大学附属肿瘤医院药学部,成都 610041
2. 成都中医药大学药学院,成都 611137
Keywords: Pyroptosis; Gasdermins; Anti-tumor nanotechnology system
From: Herald of Medicine 2024;43(8):1230-1235
CountryChina
Language:Chinese
Abstract: Pyroptosis is a kind of inflammatory cell death mediated by the Gasdermin family,which has made great progress in tumor therapy in recent years.Basing on that cell pyroptosis can activate the anti-tumor immune response,and tumor immunotherapy is a new field of tumor therapy,the regulation of cell pyroptosis exhibits great potential for tumor therapy.Meanwhile,nanotechnology is the key means of tumor precision treatment with the advantages of precise targeting and continuous release.Based on these current situations,this paper summarizes the drugs that activate pyroptosis and the nanocarriers that use nanotechnology to promote pyroptosis to participate in tumor therapy,and summarizes the mechanism and application of their action on pyroptosis.This paper is aimed to provide certain references for anti-tumor therapy based on pyroptosis.