Research Progress of Notch Signaling Pathway in Rheumatoid Arthritis

VernacularTitle:Notch通路在类风湿关节炎中的研究进展
Author: Yao HUANG ¹ ; Xin BA ; Zhe CHEN ; Shenghao TU
Author Information

1. 华中科技大学同济医学院附属同济医院中西医结合科,武汉 430030
Keywords: Notch pathway; Rheumatoid arthritis; Therapeutic target
From: Herald of Medicine 2024;43(7):1102-1106
CountryChina
Language:Chinese
Abstract: Notch signaling pathway regulates cell development,differentiation,proliferation,and apoptosis,one of the most important pathways that determine cell fate.Research has found that the Notch pathway is involved in developing rheumatoid arthritis(RA).In this article,we reviewed the composition,activation pathway,function,and role of the Notch pathway in RA,and analyzed the research progress of the Notch pathway in macrophages,osteoclasts,vascular endothelial cells,lymphocytes,and fibroblast-like synovial cells.Further exploration of the mechanism of the Notch pathway in RA can provide direction for clinical drug development and new targets for treating RA.