Prospects of Peripheral Brain-derived Extracellular Vesicles as Biomarkers for Neuropsychiatric Disorders and Treatment Monitoring
10.3870/j.issn.1004-0781.2024.07.011
- VernacularTitle:外周脑源性细胞外囊泡作为神经精神疾病生物标志物和治疗监测标志物的前景与展望
- Author:
Xinhui XIE
1
;
Shuxian XU
;
Zhongchun LIU
Author Information
1. 武汉大学人民医院精神科,武汉 430060
- Keywords:
Extracellular vesicles;
Brain-derived extracellular vesicles;
Central nervous system;
Neuropsychiatric disorder;
Biomarker;
Therapeutic drug monitoring
- From:
Herald of Medicine
2024;43(7):1084-1089
- CountryChina
- Language:Chinese
-
Abstract:
Extracellular vesicles(EV)are a group of membrane-bound structures that originate from the endosomal system or are shed from the plasma membrane of cells.EVs can carry a heterogeneous set of molecules,including proteins,lipids,nucleic acids,and membrane receptors from their cell of origin.EV can cross the blood-brain barrier,allowing brain-derived EV(BDEV)to be specifically extracted from peripheral blood using surface markers on neuronal cells.Due to the presence of signals from the central nervous system,such as proteins,lipids,and nucleic acids,BDEV has emerged as a promising tool for exploring the central nervous system.This article provided an overview of the feasibility of BDEV as biomarkers for neurological and psychiatric disorders,as well as their potential for monitoring therapeutic efficacy in the treatment process.
