Pharmacy Practice Guidelines for the Prevention and Treatment of Thromboembolic Diseases in Children
10.3870/j.issn.1004-0781.2024.07.001
- VernacularTitle:儿童血栓性疾病防治药学实践指南
- Author:
Sichuan Academy of Medical Sciences&Sichuan Provincial People's Hospital
;
School of Medicine,University of Electronic Science and Technology of China
;
Personalized Drug Therapy Key Laboratory of Sichuan Province
;
Clinical Pharmacy Branch,Chinese Medical Association
;
Cardiovascular Pharmacy Branch,Chinese Society of Cardiothoracic and Vascular Anesthesiology
- Keywords:
Thrombosis in children;
Rational medication use;
Thrombosis prevention and treatment;
Pharmacy practice guideline
- From:
Herald of Medicine
2024;43(7):1017-1038
- CountryChina
- Language:Chinese
-
Abstract:
Objective In order to improve the rationalization of medication use for thrombosis prevention and treatment in children,the guideline aims to develop a comprehensive and practical guideline for pharmacy practice in the prevention and treatment of thromboembolic diseases in children.Through a systematic review of the available evidence-based medical evidence,specific recommendations for drug prevention and treatment are presented.Methods The World Health Organization(WHO)guideline development manual was used for the study design of the guideline.A systematic search and extensive collection of common medication problems for the prevention and treatment of thrombosis in children existed nationwide,and the Delphi method was used to research experts and determine the final clinical problems to be included.Then,a systematic literature search was conducted to comprehensively assess the existing original studies,systematic evaluations,and guidelines or consensus of professional organizations.Quality evaluation was conducted according to the grades of recommendations assessment,development and evaluation(GRADE)method,and consensus on the recommendations and level of evidence was reached again through the Delphi method,which ultimately led to the formation of the pharmacy practice guidelines for the prevention and treatment of thromboembolic diseases in children.Results A total of 29 clinical problems assessed by 74 experts in clinical pharmacy and clinical medicine were collected during the development of the guideline;15 clinical problems were screened through two rounds of questionnaires;and 15 clinical medication recommendations were developed under the supervision of two methodologists.Conclusion By comprehensively evaluating the feasibility and safety of clinical practice,the guideline will provide specific antithrombotic medication recommendations for pediatric healthcare professionals,which will help improve the prevention and treatment of thrombosis in children and promote more standardized and effective medical practice.
