The Investigation on the Physical Compatibility of Admixture of CisplatinInjection with 6 Proton Pump Inhibitors
10.3870/j.issn.1004-0781.2024.06.019
- VernacularTitle:顺铂注射液与6种质子泵抑制剂配伍溶液物理相容性考察
- Author:
Tong TONG
1
;
Haiwen DING
;
Sheng LIU
;
Liqin TANG
Author Information
1. 中国科学技术大学附属第一医院(安徽省立医院)药学部,合肥 230001
- Keywords:
Cisplatin injection;
Proton pump inhibitors;
Physical compatibility;
Tyndall effect;
Insoluble particles;
Turbidity;
Ultraviolet absorbance value
- From:
Herald of Medicine
2024;43(6):965-969
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the physical compatibility of admixture of cisplatin injection with 6 proton pump inhibitors.Methods At room temperature,cisplatin solutions at low,medium and high prepared concentrations(0.06,0.09,0.12 mg·mL-1)were mixed with the same volume of injection solutions of pantoprazole sodium,esomeprazole sodium,omeprazole sodium,rabeprazole sodium,lansoprazole sodium and ilaprazole sodium infusion,respectively.The changes of appearance,Tyndall effect,pH value,turbidity,the number of insoluble particles and UV absorbance of the admixtures were investigated within 8 h.Results The admixtures of cisplatin with pantoprazole sodium,esomeprazole,omeprazole sodium and rabeprazole sodium were clear and transparent within 8 h,and the change of pH value,turbidity changes,insoluble particles,UV absorbance value changes met the requirements.The combination of low concentration cisplatin and lansoprazole sodium was physically compatible and stable within 8 h.The number of insoluble particles in medium did not meet the requirements when high concentration cisplatin combined with lansoprazole sodium.All the indexes did not meet the requirements when cisplatin were combined with ilaprazole sodium.Conclusions Low concentration cisplatin is compatible with Lansoprazole sodium within 4 h at room temperature.Low,medium and high concentrations of cisplatin were compatible with pantoprazole sodium,esomeprazole sodium,omeprazole sodium and rabeprazole sodium within 8 h.High concentrations of cisplatin is incompatible with lansoprazole sodium.Cisplatin with low,medium and high concentrations are incompatible with iprrazole sodium.
