Identification of the Antioxidant of Chrysanthemum morifolium Using Entropy-weighted TOPSIS Method Combined with Spectrum-effect Analysis
10.3870/j.issn.1004-0781.2024.06.018
- VernacularTitle:熵权逼近理想排序法结合谱效分析辨识菊花抗氧化功能的物质基础
- Author:
Qianqian ZHU
1
;
Shiqin WANG
;
Xuxiang ZHOU
;
Ruili NIE
;
Jianting ZHAN
;
Bo WANG
;
Jing NIE
;
Xiaochuan YE
;
Dan LIU
Author Information
1. 湖北中医药大学药学院中药资源与中药化学湖北省重点实验室,武汉 430065
- Keywords:
Chrysanthemum morifolium;
Fingerprint;
Antioxidant activity;
Entropy weight and TOPSIS methodology;
Spectrum-effect relationship;
Material basis
- From:
Herald of Medicine
2024;43(6):956-964
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the antioxidant function of Chrysanthemum morifolium from different origins and to identify their antioxidant material basis.Methods The HPLC fingerprints of the water extracts of C.morifolium from different origins were established.The antioxidant activities of C.morifolium were assayed by measuring the 2.2-diphenyl-l-picrylhydrazyl(DPPH),hydroxyl radical,ABTS,superoxide anion radical scavenging capacity and ferric ion reducing capacity FRAP.Entropy-weighted TOPSIS was used to calculate the weighting coefficients of the single indexes.Grey relational analysis(GRA)and partial least squares were used for spectrum-effect analysis to identify the antioxidant material basis of C.morifolium.Results A total of 16 common peaks were discovered in the fingerprint of the water extracts of 10 batches of C.morifolium,among which 13 common components were identified.All the C.morifolium samples had good antioxidant capacity,and the results of entropy-weighted TOPSIS analysis showed that the ranking of total antioxidant potency of 10 batches of C.morifolium was follows:S1＞S8＞S3＞S5＞S4＞S10＞S7＞S2＞S9＞S6.The peaks of 1-5,9,10,12,14 were positively correlated with the antioxidant activity and the variable influence on projection(VIP)values were greater than 1.The correlation coefficients of these nine peaks in GRA were all greater than 0.7.Conclusion The entropy-weighted TOPSIS method combined with the spectrum-effect analysis could be used to screen out the antioxidant material basis of C.morifolium and the results provide a basis for establishing quality assessment system for C.morifolium based on Quality-markers thus improving the quality control level.
