Research Advances on Drugs Delivery Carriers for Messenger Ribonucleic Acid Drugs

VernacularTitle:信使核糖核酸药物递送载体的研究进展
Author: Yuanyuan ZHAO ¹ ; Qianru ZHANG ; Huanhuan XU ; Yanmei XU
Author Information

1. 河北省药品医疗器械检验研究院,石家庄 050200
Keywords: Messenger ribonucleic acid; Delivery carriers; Lipids; Polymer; Peptide
From: Herald of Medicine 2024;43(6):930-935
CountryChina
Language:Chinese
Abstract: As a noval class of nucleic acid drugs,messenger ribonucleic acid(mRNA)has great application potential in vaccines,immunotherapy,regenerative medicine,gene editing and so on.In particular,coronavirus disease 2019(COVID-19)in 2020 has greatly accelerated the mRNA technology development globally.However,mRNA being negatively charged,face challenges in cell entry and is easy to be phagocytized by cells of the innate immune system or degraded by nucleases in vivo.The instability and low delivery efficiency hinder widespread application of mRNA-based therapy.Therefore,safe,effective and stable delivery was needed carriers to protect mRNA from degradation and break through the barrier of cell membrane in order to ensure it express in intracellular.This paper systematically reviews the latest research progress of mRNA delivery carriers and briefly describes lipid carriers,polymer carriers,peptide carriers and viral carriers.The future directions of mRNA delivery carriers research are prospected so as to provide reference for the development of new mRNA drug delivery carriers.