Research Progress on the Therapeutic Effect and Mechanism of Harmine in Alzheimer's Disease
10.3870/j.issn.1004-0781.2024.06.013
- VernacularTitle:去氢骆驼蓬碱改善阿尔茨海默病作用及其机制研究进展
- Author:
Nianzhuang QIU
1
;
Meng ZHANG
;
Mei LI
;
Tianyang GUO
;
Yuli LYU
;
Xuehui ZHANG
;
Hao WANG
Author Information
1. 山东第一医科大学药理学研究所,泰安 271016
- Keywords:
Harmine;
Alzheimer's disease;
β-amyloid protein
- From:
Herald of Medicine
2024;43(6):925-929
- CountryChina
- Language:Chinese
-
Abstract:
Harmine(HM)is a type of β-Carboline alkaloid abundant in nature and has many biological effects.In recent years.Studies have found that HM had a significant positive effect on Alzheimer's disease(AD)both in vivo and in vitro.Its mechanism may be related to the reduction of abnormal deposition of β-amyloid protein(Aβ),excessive phosphorylation of Tau protein,regulation of the cholinergic system,antioxidant stress,and antineuritis.This article reviews the research progress on the improvement effect and mechanism of HM in AD in order to provide an experimental basis for the clinical application of HM and the development of drugs in the area of AD the prevention and treatment.
