Research Progress on Preparation and Anti-osteoarthritis Activity of Chondroitin Sulfate Sodium
10.3870/j.issn.1004-0781.2024.06.012
- VernacularTitle:硫酸软骨素钠的制备及抗骨关节炎活性研究进展
- Author:
Lin ZHAO
1
;
Zhenyu YUN
;
Xi WU
;
Mengyan ZHANG
;
Yu JIANG
;
Hongyu LIU
;
Tao LAN
;
Xiuwen YIN
Author Information
1. 中国标准化研究院农业食品标准化研究所,北京 100191
- Keywords:
Chondroitin sulfate sodium;
Preparation technique;
Anti-osteoarthritis activity
- From:
Herald of Medicine
2024;43(6):916-925
- CountryChina
- Language:Chinese
-
Abstract:
Chondroitin sulfate sodium is a sulphated glycosaminoglycan composed of repeating disaccharide units of D-glucuronic acid and N-acetyl-D-galactosamine,prepared from the cartilage tissue of land or marine animal by a specific extraction and purification process.Chondroitin sulfate sodium is considered to have anti-osteoarthritis effect and many other potential physiological activities.It has broad application prospects and development space in the fields of health food,cosmetics,and drugs.This paper reviews the preparation process of chondroitin sulfate sodium,development and problems of microbial synthesis technology and the research status of anti-osteoarthritis activity based on cells models,animal models and clinical randomized controlled trials(RCT).The limitations of current research are analyzed and corresponding strategies are proposed to provide reference for further standardization and development of chondroitin sulfate sodium.
