A summary of the best evidence for the prevention of oral mucositis associated with radiotherapy and chemotherapy in children with hematological tumors
10.3760/cma.j.cn115682-20200815-04911
- VernacularTitle:血液肿瘤患儿放化疗相关口腔黏膜炎预防的最佳证据总结
- Author:
Lianye LI
1
;
Chunli WANG
;
Xinyi WU
;
Fangjiao CHEN
;
Rui LIANG
;
Ying GU
Author Information
1. 国家儿童医学中心（北京），首都医科大学附属北京儿童医院重症医学科 100045
- Keywords:
Child;
Hematologic neoplasms;
Oral mucositis;
Best practice;
Radiotherapy;
Chemotherapy
- From:
Chinese Journal of Modern Nursing
2021;27(15):1992-1997
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To retrieve, evaluate and integrate domestic and foreign relevant evidence on the prevention of oral mucositis related to chemoradiotherapy in children, and summarize the best evidence, so as to provide clinical practice guidelines for medical staff.Methods:We systematically searched the evidence on the prevention of oral mucositis related to chemoradiotherapy in children in British Medical Journal (BMJ) Best Practice, UpToDate, Joanna Briggs Institute (JBI) Evidence-based Health Care Center Database, National Guideline Clearinghouse, Registered Nurses' Association of Ontario, Scottish Intercollegiate Guidelines Network, United Kingdom National Institute for Health and Care Excellence, International Practice Guideline Registry Platform (Chinese) , Multinational Association of Supportive Care in Cancer, International Society of Oral Oncology, European Society for Medical Oncology, American Society of Clinical Oncology, Cochrane Library, BMJ Journals, PubMed, Embase, China National Knowledge Infrastructure (CNKI) , WanFang Data and China Biology Medicine Database. The evidence included clinical practice guidelines, expert consensus, best practices, systematic reviews and evidence summaries, and the search time limit was to build the database until November 1, 2019. The searched guidelines were independently evaluated by four guideline reviewers, and the rest of literature was independently evaluated by two researchers who received evidence-based training to evaluate the quality of the included literature, combined with the judgment of professionals. Evidence extraction and evidence summary were carried out on literature that met the quality standards.Results:A total of 8 articles were included, including 1 BMJ best practice, 5 JBI evidence summaries, 1 guideline, and 1 systematic review. The best evidence included 16 pieces of evidence in 7 areas of basic oral care, nursing evaluation, diet prevention, physical therapy, drug prevention, fungal infection prevention, and multidisciplinary team management.Conclusions:This study summarizes the best evidence for the prevention of oral mucositis related to chemoradiotherapy in children, and provides clinical practice guidelines for medical staff. Medical institutions should establish preventive measures for children's oral mucositis related to chemoradiotherapy based on the transformation of evidence-based evidence, and establish standardized multidisciplinary collaboration and nursing procedures to improve patient health outcomes.
