Predictive Value of Combining the Level of Antithrombin Ⅲ and Procalcitonin for SA-AKI
10.11969/j.issn.1673-548X.2024.10.029
- VernacularTitle:抗凝血酶Ⅲ联合降钙素原在SA-AKI中的预测价值
- Author:
Yanhu SUN
1
;
Yawen LIU
;
Weitao SHI
Author Information
1. 221000 徐州市第一人民医院重症医学科、徐州医科大学附属徐州市立医院重症医学科
- Keywords:
Sepsis;
Acute kidney injury;
Antithrombin Ⅲ;
Procalcitonin
- From:
Journal of Medical Research
2024;53(10):161-165
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the predictive effect of antithrombin Ⅲ(AT-Ⅲ)combined with procalcitonin(PCT)on sepsis-associated acute kidney injury(SA-AKI).Methods A total of 96 patients with sepsis who met the inclusion criteria were in-cluded,all patients were divided into the AKI group(n=42)and non-AKI group(n=54),and the data between the two groups were compared.We used the receiver operating characteristic(ROC)curves to evaluate the predictive effect of antithrombin Ⅲ level,procalCI tonin level,and combination on SA-AKI.Multivariate Logistic regression analysis was used to study the influencing factors of SA-AKI.Results The proportion of PCT,CRP,fibrinogen,SOFA score,APACHE Ⅱ score,vasoactive drug use,and blood purification applica-tion in the AKI group was higher than that in the non-AKI group(P＜0.05),as well as the AT-Ⅲ,and platelet count were lower than those in the non-AKI group(P＜0.05).The area under the ROC curve for predicting SA-AKI in patients with sepsis was 0.876(95％CI:0.793-0.935,P＜0.01),the sensitivity was 78.6％,and the specificity was 88.9％.Multivariate Logistic regression anal-ysis showed that AT-Ⅲ(OR=0.907,95％CI:0.860-0.956)and PCT(OR=1.037,95％CI:1.002-1.074)were independent influencing factors for SA-AKI.Conclusion AT-Ⅲ combined with PCT could be used to predict SA-AKI and has good predictive ef-ficacy.
