The Effects of Reminazolam and Midazolam on Postoperative Delirium in Patients with Congenital Heart Disease
10.11969/j.issn.1673-548X.2024.10.025
- VernacularTitle:瑞马唑仑与咪达唑仑对先天性心脏病患者术后谵妄的影响
- Author:
Ping HAN
1
;
Yibei WU
;
Chunxiang LI
Author Information
1. 200120 上海交通大学医学院附属上海儿童医学中心
- Keywords:
Postoperative delirium;
Reminazolam;
Congenital heart disease
- From:
Journal of Medical Research
2024;53(10):140-143,139
- CountryChina
- Language:Chinese
-
Abstract:
Objective The purpose of this study is to explore the effects of reminazolam and midazolam on the occurrence of deliri-um in postoperative patients with congenital heart disease.Methods A total of 131 postoperative patients with congenital heart disease were admitted to our hospital from March to August 2023,they were randomly divided into a reminazolam group(n=66)and a midazolam group(n=65).The Cornell Delirium Assessment Scale for Children was used to evaluate postoperative delirium.We analyzed and com-pared the incidence,occurrence time,and duration of the two groups.We also recorded the patient's adverse drug reactions,mechanical ventilation time,cardiac intensive care unit(CICU)stay time,and hospitalization time.Results The incidence of delirium was 51.7％in the midazolam group and 40.0％in the reminazolam group,with no statistically significant difference.However,there were significant differences in the timing of delirium occurrence between the two groups(x2=12.400,P=0.030).The duration of delirium in the remi-nazolam group was significantly shortened(x2=14.773,P=0.034).There was no statistically significant difference between the two groups in mechanical ventilation and CICU retention time.There was a difference in hospitalization time between the two groups(z=0.096,P=0.016).There were 2 cases of adverse reactions(3.08％)in the midazolam group and 5 cases(7.58％)in the reminazolam group,with no statistically significant difference.Conclusion As a benzodiazepine drug,reminazolam has a certain protective effect on postoperative delirium in patients undergoing congenital heart surgery.However,further research is needed on the application of reminazo-lam in children,including drug dosage and adverse reactions.
