Research on the Correlation between White Blood Cell Count,Serum Lipid,Blood Glucose and the Occurrence of Acute Myocardial Infarc-tion in Elderly Coronary Atherosclerotic Heart Disease
10.11969/j.issn.1673-548X.2024.10.021
- VernacularTitle:老年冠心病患者白细胞计数、血脂及血糖水平与发生急性心肌梗死的相关性研究
- Author:
Nan SHEN
1
;
Zhengran LV
;
Wenqi WU
Author Information
1. 200000 上海交通大学医学院附属新华医院
- Keywords:
Elderly coronary atherosclerotic heart disease;
Acute myocardial infarction;
White blood cell count;
LDL-C;
Fast-ing blood glucose
- From:
Journal of Medical Research
2024;53(10):118-122
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the predictive value of white blood cell count,LDL-C and fasting blood glucose on the occur-rence of AMI in elderly patients with coronary atherosclerotic heart disease(CAD).Methods A total of 210 elderly patients with CAD were selected and divided into the AMI group as the case group and the chronic CAD group as the control group based on clinical manifes-tations and laboratory and coronary angiography results.The general data,laboratory data,coronary angiography results,and other clinical information of the two groups were retrospectively analyzed.We used the Logistic regression analysis to explore the risk factors for acute myocardial infarction in elderly CAD patients and the receiver operating characteristic curve(ROC)to evaluate the predictive efficacy of white blood cell count,LDL-C and fasting blood glucose on the occurrence of AMI in elderly CAD patients.Results Compared with the chronic CAD group,the AMI group had a higher smoking rate,white blood cell count,CRP,ALT,AST,D-D dimer,fasting blood glu-cose,total cholesterol,LDL-C and Gensini score and lower LVEF(P＜0.05).The Logistic regression analysis showed that white blood cell count(β=0.859,P＜0.001,OR=2.361),LDL-C(β=1.003,P=0.009,OR=2.728)and fasting blood glucose(β=0.495,P=0.007,OR=1.641)were independent risk factors for AMI in elderly CAD patients.The ROC curve analysis showed that when the cut-off values of fasting blood glucose,white blood cell count,and LDL-C were 4.895mmol/L,7.19 x 109/L and 2.635 mmol/L respectively,the area under the curve for predicting AMI was the largest,with values of 0.734,0.859 and 0.735.The area un-der the ROC curve of the combination of the three is 0.902.Conclusion White blood cell count,LDL-C and fasting blood glucose are associated with AMI in elderly patients with CAD.Higher levels of white blood cell count,LDL-C and fasting blood glucose indicate a higher risk of AMI.The combination of the three can serve as a more valuable predictive index.
