Relationship Between COL1A2 Expression and Clinicopathological Characteristics and Prognosis of Lung Adenocarcinoma
10.11969/j.issn.1673-548X.2024.09.031
- VernacularTitle:COL1A2的表达与肺腺癌临床病理特征及预后的关系
- Author:
Xiaoxuan YANG
1
;
Yanling WANG
;
Jing LI
Author Information
1. 832000 石河子大学医学院
- Keywords:
COL1A2;
Lung adenocarcinoma;
Clinicopathological characteristics;
Prognosis;
Immunohistochemistry
- From:
Journal of Medical Research
2024;53(9):157-161
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between COL1A2 expression and clinicopathological characteristics and prog-nosis of patients with lung adenocarcinoma.Methods The RNA-Seq expression profile of TCGA-lung adenocarcinoma and corre-sponding clinical data were downloaded from The Cancer Genome Atlas(TCGA)database,bioinformatics was used to analyze the correla-tion between the differential expression of COL1A2 in lung adenocarcinoma tissues compared to normal lung tissues and the survival rate of patients with lung adenocarcinoma.Eighty-two patients with lung adenocarcinoma were selected from January 2018 to December 2020 in the First Affiliated Hospital of Shihezi University.Using immunohistochemistry to verify the relationship between COL1A2 expression and clinicopathological characteristics and prognosis of patients with lung adenocarcinoma.Results COL1A2 was highly expressed in lung ad-enocarcinoma tissues(P＜0.05).Immunohistochemistry indicated that COL1A2 expression was associated with tumour stage and the presence of distant metastases(P＜0.05).Kaplan-Meier survival analysis indicated COL1A2 expression was associated with the progno-sis of patients with lung adenocarcinoma(x2=9.639,P=0.002).Multivariate COX regression analysis showed that high expression of COL1A2 was an independent risk factor for prognosis of patients with lung adenocarcinoma(HR=2.657,95％CI:1.062-6.646,P=0.037).Conclusion The expression of COL1A2 is elevated in lung adenocarcinoma,which correlates with tumour stage,presence of distant metastasis and prognosis of patients with lung adenocarcinoma.
