Effect of AMH Levels on Embryo Quality and Clinical Outcomes of Fresh Embryo Transfer in Young Infertile Female Patients Undergoing IVF/ICSI Treatment
10.11969/j.issn.1673-548X.2024.09.029
- VernacularTitle:AMH水平对年轻不孕女性行IVF/ICSI治疗后胚胎质量及鲜胚移植临床结局的影响
- Author:
Jiating MAO
1
;
Keda YU
;
Juan CHAI
Author Information
1. 321000 金华市人民医院生殖医学中心
- Keywords:
AMH;
IVF/ICSI;
Embryo development;
Clinical outcomes
- From:
Journal of Medical Research
2024;53(9):147-151
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the impact of different levels of anti-Müllerian hormone(AMH)on embryo quality and clini-cal outcomes of fresh embryo transplantation in young infertile female patients undergoing treatment with in vitro fertilization/intracytoplas-mic sperm injection(IVF/ICSI).Methods The clinical data of 528 young infertile female patients who underwent IVF/ICSI treatment at the Center of Reproductive Medicine,Jinhua People's Hospital from January 2020 to December 2021 were retrospectively analyzed,and they were divided into three groups based on serum AMH levels:low AMH group(n=93),medium AMH group(n=273)and high AMH group(n=162).Baseline information,laboratory indicators,and clinical outcomes of the three groups were compared.Multiple linear regression analysis was used to determine the correlation between AMH and various laboratory indicators,Logistic regression analysis was adopted to correct for the impact of different baseline information on clinical outcomes in three groups.Results The results of multi-ple linear regression analysis showed that the level of AMH was an independent factor affecting the number of retrieved oocytes and normal fertilization rate,and positively correlated to the number of retrieved oocytes(β=0.630,95％CI:0.405-0.854,P＜0.05),and nega-tively correlated with normal fertilization rate(β=-1.965,95％CI:-2.897-1.033,P＜0.05).The results of Logistic regression a-nalysis showed that there was no significant difference in clinical outcomes among different AMH groups(P＞0.05).Conclusion AMH is an independent influencing factor for predicting the number of retrieved oocytes and normal fertilization rate in young infertile female pa-tients,and AMH is a good indicator of ovarian reserve capacity,but it has no significant ability to predict clinical outcomes in fresh em-bryo transplantation.Even those with low AMH can achieve satisfactory pregnancy outcomes as long as they obtain embryos,and high AMH does not necessarily mean they can achieve better pregnancy outcomes.
