Clinical Effects of Shugan Yishen Recipe on Postmenopausal Estrogen Receptor-positive Breast Cancer Patients with Hepatic Stagnation and Spleen Deficiency Type
10.11969/j.issn.1673-548X.2024.09.023
- VernacularTitle:疏肝益肾方治疗肝郁脾虚型绝经后雌激素受体阳性乳腺癌术后患者的临床疗效
- Author:
Shiyun ZHENG
1
;
Chuang CUI
;
Wanqing CHEN
Author Information
1. 200071 上海中医药大学附属市中医医院
- Keywords:
Breast cancer;
Endocrine therapy;
Bone metabolism;
Aromatase inhibitor;
Shugan yishen recipe
- From:
Journal of Medical Research
2024;53(9):117-121
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy of shugan yishen recipe in the treatment of postmenopausal estrogen receptor-positive breast cancer patients during endocrine therapy.Methods A total of 110 postmenopausal breast cancer patients undergoing aro-matase inhibitor endocrine therapy at Shanghai Municipal Hospital of Traditional Chinese Medicine from July 2021 to September 2023 were divided into observation group and control group by random number table method,with 55 patients in each group..Both groups received standard treatment;the observation group also took shugan yishen recipe,while the control group also took shugan yishen recipe placebo,treatment for 12 weeks.The clinical efficacy,traditional Chinese medicine syndrome scores,bone metabolism,tumor markers,T-cell subsets(CD4+,CD8+,CD4+/CD8+)of the two groups were observed,and the safety was evaluated.Results A total of 106 patients completed the experiment,with 53 patients in each group.After treatment,the total clinical effective rate was 75.5％in the observation group,and 58.5％in the control group,the clinical effect of the observation group was better than that of the control group(P＜0.01).Compared with before treatment,TCM syndrome scores in both groups were decreased(P＜0.01).After treatment,β-c-terminal te-lopeptide of type-Ⅰ collagen(β-CTX),carbohydrate antigen 125(CA125),carbohydrate antigen 153(CA153)and CD8+were all decreased compared with those before treatment(P＜0.05);N-mid osteocalcin(N-MID),CD4+,CD4+/CD8+were higher than those before treatment(P＜0.01).After treatment,β-CTX,N-MID,CA153,CD8+and CD4+/CD8+in the observation group were significantly better than those in the control group(P＜0.01).Conclusion Shugan yishen recipe can improve bone metabolism abnor-malities caused by endocrine treatment in postmenopausal patients with estrogen receptor-positive breast cancer,reduce serum tumor marker levels,enhance immune function of patients,and is safe and effective.
