Clinical Study of Chaizhu Liwei Yin Combined with Domperidone in the Treatment of Elderly Patients with Spleen Deficiency Qi Stagnation FD and Sleep Disorder
10.11969/j.issn.1673-548X.2024.08.026
- VernacularTitle:柴术理胃饮联合多潘立酮治疗老年脾虚气滞型FD伴睡眠障碍临床研究
- Author:
Mingming FAN
1
;
Yichuan ZHANG
;
Yongmei LIU
Author Information
1. 150036 哈尔滨,黑龙江省中医药科学院
- Keywords:
Functional dyspepsia;
Chaizhu Liwei Yin;
Sleep disorder;
Spleen deficiency and qi stagnation;
Thinning wood and cul-tivating soil
- From:
Journal of Medical Research
2024;53(8):137-140
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy of chaizhu liwei yin combined with domperidone in the treatment of functional dyspepsia(FD)with spleen deficiency and qi stagnation stype accompanied by sleep disorders.Methods A total of 80 elderly patients with FD with spleen deficiency and qi stagnation stype accompanied by sleep disorders in the Geriatric Clinic,Nangang Hospital of Hei-longjiang Academy of Chinese Medicine from September 2020 to September 2022 were selected as the research objects,and they were ran-domly divided into the observation group and the control group,with 40 cases in each group.The observation group was treated with domp-eridone tablets combined with chaizhu liwei yin,while the control group was treated with domperidone tablets,the patients in the two groups were given continuous administration for 4 weeks.The clinical efficacy,TCM syndrome efficacy evaluation score,Nepean dyspep-sia index(NDI)and Pittsburgh sleep quality index(PSQI)were observed before and after treatment in the two groups of elderly FD pa-tients.Results During the treatment,1 case was shed in the control group and 2 cases in the observation group.77 patients were includ-ed in the curative effect observation statistics,including 39 cases in the control group and 38 cases in the observation group.After treat-ment,the total effective rate of clinical symptoms in the observation group and the control group was 86.84％and 69.23％,respectively,and the observation group was better than the control group(P＜0.05).the scores of TCM syndrome efficacy evaluation in observation group and control group were lower than before treatment(P＜0.05),and the observation group was lower than the control group(P＜0.05);NDI scores of the observation group(77.13±5.62)and control group(61.03±5.33)were both improved compared with before treatment(P＜0.05),and the improvement of the observation group was higher than that of the control group(P＜0.05);the total scores of PSQI in the observation group(5.23±1.52)and control group(7.74±2.17)were lower than before treatment(P＜0.05),and the total scores of PSQI in the observation group was lower than that in the control group(P＜0.05);During the observation period,there were no obvious adverse reactions in the observation group and the control group,indicating the safety was high.Conclusion Chai liwei yin combined with domperidone can effectively relieve gastrointestinal symptoms in elderly FD patients with spleen deficiency and qi stagnation stype,improve sleep status and improve the quality of life in elderly patients.
