Meta-analysis of Efficacy and Safety of Compound Duzhong Jiangu Granules in the Treatment of Knee Osteoarthritis
10.11969/j.issn.1673-548X.2024.08.017
- VernacularTitle:复方杜仲健骨颗粒治疗膝骨关节炎的有效性及安全性Meta分析
- Author:
Yishan CHEN
1
;
Tianyuan WANG
;
Jing HU
Author Information
1. 100010 首都医科大学附属北京中医医院、北京市中医药研究所、北京中医药循证医学中心
- Keywords:
Duzhong jiangu granules;
Knee osteoarthritis;
Meta-analysis;
Curative effect evaluation
- From:
Journal of Medical Research
2024;53(8):85-91
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically evaluate the efficacy and safety of compound Duzhong Jiangu granules in the treatment of knee osteoarthritis.Methods According to PICOS principle,literature retrieval was carried out in CNKI,SinoMed,VIP,WanFang,PubMed,Medline,Embase and Cochrane Library,and the retrieval time was up to October 2023.Meta-analysis was performed on quan-tifiable studies,and the effective rate and efficacy indicators were combined.Results A total of 5 articles were included for Meta-anal-ysis.The effective rate of compound guzhong Jiangu granules was higher than that of control group,the difference was statistically signifi-cant(RR=1.12,95％CI:1.07-1.18,P＜0.001).Compared with the control group,there were significant differences in pain or discomfort scores during bed rest at night,standing from seat score,maximum walking distance score,getting off standard ladder score,walking on uneven road score and WOMAC score between compound duzhong jiangu granules and the control group(P＜0.01).There were no significant differences in improving morning stiffness or pain after getting up,boarding standard ladder score and joint function ef-ficacy score between compound Duzhong Jiangu Granules and control group(P＞0.05).There were no serious adverse events were repor-ted in the included studies.Conclusion Combined with compound guzhong jiangu granules can improve the therapeutic effect of knee os-teoarthritis,relieve a mild to moderate pain to a certain extent,and promote the recovery of joint function,but it is not good for improving morning stiffness,so it is recommended for early combined treatment with good safety.
