Chemopreventive Action of Anthocyanin-rich Black Soybean Fraction in APC(Min/+) Intestinal Polyposis Model.
10.15430/JCP.2015.20.3.193
- Author:
Mi Young PARK
1
;
Jung Mi KIM
;
Jong Sang KIM
;
Myoung Gun CHOUNG
;
Mi Kyung SUNG
Author Information
1. Department of Food and Nutrition Education, Graduate School of Education, Soonchunhyang University, Asan, Korea.
- Publication Type:Original Article
- Keywords:
Anthocyanins;
APC(Min/+);
Black soybean;
Inflammation;
Intestinal tumors
- MeSH:
Animals;
Anthocyanins;
beta Catenin;
Carcinogenesis;
Cyclooxygenase 2;
Cytosol;
Diet;
Inflammation;
Intestinal Polyposis*;
Mice;
Mucous Membrane;
Oxidative Stress;
Phospholipases A2;
Soybeans*
- From:Journal of Cancer Prevention
2015;20(3):193-201
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Anthocyanins have been shown to inhibit cancer cell growth by suppressing oxidative stress and inflammatory responses. The purpose of this study was to investigate the effects of an anthocyanin-rich extract (AE) from black soybean coat on intestinal carcinogenesis. METHODS: APC(Min/+) mice were fed a diet of 0.2% or 0.5% AE for 7 weeks. We analyzed the number of intestinal tumors, oxidative stress and inflammatory markers associated with beta-catenin and cytosolic phospholipase A2 (cPLA2) signals. The number of intestinal tumors, and cellular expression of beta-catenin were determined. RESULTS: The number of intestinal tumors was significantly lower in mice fed a 0.5% AE diet compared to those of the other groups. Cytosolic beta-catenin expression was significantly decreased in the AE supplemented groups compared to that of the control animals. In addition, mucosa expression of cyclooxygenase-2 and cPLA2 were also significantly decreased in the 0.5% AE group, by 32% and 62%, respectively, compared to the control group. CONCLUSIONS: These results suggest that dietary AE reduced the development of intestinal tumors, possibly through the ability to suppress oxidative stresses, decreasing inflammatory responses mediated by beta-catenin associated signals.
