Patterns of Immunocyte Infiltration in Ovarian Cancer and Their Clinical Significance
10.11969/j.issn.1673-548X.2024.06.007
- VernacularTitle:卵巢癌免疫细胞浸润模式及其临床意义
- Author:
Tiefeng CAO
1
;
Jiaming HUANG
;
Yushi HE
Author Information
1. 510080 广州,中山大学附属第一医院妇科
- Keywords:
Immune infiltration;
Deconvolution;
Ovarian cancer;
Clinical outcome;
Chemotherapy response
- From:
Journal of Medical Research
2024;53(6):29-34
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the patterns of the immunocyte infiltration in ovarian cancer,and their influence on clinical out-come and chemotherapy response.Methods The clinical information and gene expression profiles of 2206 ovarian cancer patients were downloaded from TCGA and GEO publicly databases.The CIBERSORT was used to evaluate the distribution of 22 immune cells and their effects on survival,and chemotherapy response.Unsupervised clustering was used to classify cases and analyze differences in clinical out-comes between subgroups.Immunofluorescence staining was performed to illustrate the macrophages infiltration in ovarian cancer samples collected from the First Affiliated Hospital,Sun Yat-sen University.Results Naive B cells,M2 macrophages,and resting memory CD4+T cells were significantly associated with poor prognosis,while follicular helper T cells were significantly associated with good prog-nosis.Plasma cells,M1 macrophages,and activated memory CD4+T cells were associated with chemotherapy sensitivity,and M2 macro-phages were associated with chemotherapy resistant.Furthermore,three subgroups were identified by unsupervised clustering which showed different distribution ratios of macrophages and T cells,and significant differences in overall survival among subgroups.The infil-tration of macrophages in metastasis tissue of ovarian cancer was more than that in primary tumor.Conclusion The immunocyte infiltra-tion in ovarian cancer is associated with clinical prognosis and chemotherapy resistance.Immune cell targeting therapy or combination chemotherapy may be the potential treatment choices for ovarian cancer.
